Viagra, Sildenafil citrate may help type 2 diabetes mellitus and coronary artery diseas :
Viagra(sildenafil citrate) relaxes the muscle cells in the blood vessels supplying the penis, allowing an increased blood flow.This flowing of blood into the penis helps in erection.
Sildenafil, vardenafil, tadalafil,and avanafil are classified as PDE5 inhibitors.During sexual arousal,nitric oxide is released from nerve terminals and endothelial cells in corpus cavernosum.It is responsible for prolonging an erection.For more information
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Dosage for erectile dysfunction
Viagra is a prescription medication available in three strength: 25mg,50mg,100mg.Â
You can take it 30 minutes to 1 hour before sexual activity.And you should not take without doctor consultation.
Which people should not take Viagra
- Had an allergic reaction to sildenafil.
- Patient taking medicines for chest pain called nitrates.
- Patient have a serious liver of heart problem
- Have low blood pressure
- Patient suffering from sickle cell anaemia or cancer
- Patient have any problems with your heart, kidney or liver.
- Patients are suffering from any bleeding problem like a stomach ulcer.
- Patient have blood cancer or any other blood-related condition.
- Any deformities of your penis.
- You experience sudden vision loss.
- You have sickle cell anaemia.
- You are taking medicines like nitrates.
- Women and patients less than 18 years old should not use Viagra 100 mg tablet.
According to the journal of sexual medicine(International Society Of Sexual Medicine)effect of viagra (PDE-5is) may protect men from heart attacks,stroke, cardiovascular disease and type 2 diabetes mellitus.
However, more research is needed to confirm the findings of the study.
The clinical efficacy of PDE-5is in treating ED is well known to be related to the downregulation of PDE-5 release in systemic arteries, which in turn reduces the breakdown of cyclic guanosine monophosphate (cGMP) in the penis and other organs. This pharmacologic effect is mediated via a nitric oxide (NO) mechanism, thereby enhancing vasodilation of key arteries and sinusoids in the corpus cavernosum of the penis.
Moreover, since the action of these drugs is achieved systemically, improving NO-mediated vasodilation and endothelial function with PDE-5is is not specific for the vasculature of the genitalia but involves the vasculature of all body systems.
This systemic benefit in endothelial function led to postulate that patients with other disorders associated with known endothelial dysfunction, including coronary artery disease (CAD), as well as risk factors for atherosclerosis, including type 2 diabetes mellitus (T2DM), may show benefit from therapy with these agents.
